Host-Pathogen Interaction Laboratory
© 2015 - 2016 Uzonna (Created by F. Khadem)
2015 1 . Mou,   Z.,      Li      J.,      Boussoffara      T.,   Kishi   H.,   Hamana   H.,   Ezzati      P.,      Hu      C.,      Yi      W.,      Liu      D.,      Khadem      F.,      Okwor     I.,      Jia      P.,      Shitaoka   K.,   Wang      S.,      Ndao      M.,   Petersen      C.,      Chen      J.,      Rafati      S.,      Louzir   H.,   Muraguchi   A., Wilkins    JA.,    and    Uzonna    JE.    2015.    Identification    of    broadly    conserved    cross-species    protective Leishmania   antigen   and   its   responding   CD4+   T   cells.   Sci   Trans   Med   (PMID:   26491077).             ABSTRACT               FULL TEXT 2 . Okwor,   I.,   Jia,   P.,   and   Uzonna,   J.E.   2015.   Interaction   of   macrophage   antigen-1   (MAC-1)   and   CD40   ligand leads   to   IL-12   production   and   protection   in   CD40   deficient   mice   infected   with   Leishmania   major .   J Immunol. 2015 Aug 24. pii: 1500922 . 3 . Khadem   F.,   Gao   X.,   Mou   Z.,   Jia   P.,   Movassagh   H.,   Onyilagha   C.,   Gounni   AS.,   Wright   MC.,   Uzonna   JE.   2015. Hepatic    stellate    cells    regulate    liver    immunity    to    visceral    leishmaniasis    through    p110δ-dependent induction and expansion of Tregs in mice.  Hepatology. Feb;63(2):620-32 . 4 . Okwor,   I.,   Xu,   G.,   Tang,   H.,   Liang,   Y.,   Fu.,   Y.,   and   Uzonna,   J.E.   2015.   Deficiency   of   CD40   Reveals   an Important Role for LIGHT in Anti-Leishmania Immunity. J. Immunol. 195:191-202 . 5 . Onyilagha   C,   Jia,   P.,   Jayachandran,   N.,   Hou,   S.,   Okwor   I,   Kuriakose   S,   Marshall,   A,   and   Uzonna   J.   2015.   The B   cell   adaptor   molecule   Bam32   is   critically   important   for   optimal   antibody   response   and   resistance   to experimental   Trypanosoma   congolense    infection   in   mice.   PLoS   Negl   Trop   Dis.   Apr   13;9(4):e0003716.   doi: 10.1371/journal.pntd.0003716 . 6 . Li,   J.,   Liu,   D.,   Mou,   Z,   Ihedioha,   O.,   Blanchard,   A.,   Myal   Y.,   and   Uzonna,   J.E.   2015.   Deficiency   of   prolactin- inducible   protein   leads   to   impaired   Th1   immune   response   and   susceptibility   to   Leishmania   major    in mice. Eur J Immunol. 45(4):1082-91 .
2014 1 . Khadem,   F.,   Mou,   Z.,   Liu,   D.,   Varikuti,   S.,   Satoskar,   A.,   and   Uzonna,   J.E.   2014.   Deficiency   of   p110δ   Isoform of   the   Phosphoinositide   3   Kinase   Leads   to   Enhanced   Resistance   to   Leishmania   donovani .   PLoS   Negl   Trop Dis. 2014 Jun 19;8(6):e2951 . 2 . Okwor,   I.,   Jia,   P.,   Mou,   Z.,   Onyilagha,   N.,   and   Uzonna,   J.E.   2014.   CD8 +    T   cells   are   preferentially   activated during   primary   low   dose   Leishmania   major    infection   but   are   completely   dispensable   during   secondary anti-Leishmania immunity. PLoS Negl Trop Dis. 2014 Nov 20;8(11):e3300. doi: 10.1371/ 3 . Mou,   Z.,   Liu   D.,   Okwor,   I.,   Jia,   P.,   Orihara,   K.,   and   Uzonna,   J.E.   2014.   MHC   class   II   restricted   innate-like double   negative   T   cells   contribute   to   optimal   primary   and   secondary   immunity   to   Leishmania   major . PLoS Path. 2014 Sep 18;10(9):e1004396. doi: 10.1371 4 . Okeke,   E.,   Okwor,   I.B.   and   Uzonna,   J.E.   2014.   Regulatory   T   Cells   Restrain   CD4 +    T   Cells   from   Causing Unregulated   Immune   Activation   and   Hypersensitivity   to   Lipopolysaccharide   Challenge.   J   Immunol.   Jul 15;193(2):655-62 . 5 . Kuriakose,   S.,   and   Uzonna,   J.E.   2014.   Diminazene   aceturate   (Berenil),   a   new   use   for   an   old   compound. Int Immunopharmacol. Aug;21(2):342-5 . 6 . Khadem,   F.   and   Uzonna,   J.E.   2014.   Immunity   to   visceral   leishmaniasis:   implications   for   immunotherapy. Future Microbiol 9:901-915 . 7 . Onyilagha   C,   Okwor   I,   Kuriakose   S,   Singh   R,   Uzonna   J.   Low-Dose   Intradermal   Infection   with   Trypanosoma congolense    Leads   to   Expansion   of   Regulatory   T   Cells   and   Enhanced   Susceptibility   to   Reinfection.   Infect Immun. 2014 Mar;82(3):1074-83. doi: 10.1128/IAI.01028-13 .
2013 1 . Liu,   D.,   Mou,   Z.,   Okwor,   I.,   Beverley,   S.,   and   Uzonna,   J.   2013.   Deficiency   of   Leishmania   phosphoglycans   influences   the   magnitude   but   does   not affect the quality of secondary (memory) anti-Leishmania immunity. PLoS One. 11;8(6):e66058. doi: 10.1371/journal.pone.0066058 2 . Kuriakose   S,   Muleme   H,   Onyilagha   C,   Okeke   E,   Uzonna   JE.   2013   Diminazene   aceturate   (Berenil)   modulates   LPS   induced   pro-inflammatory   cytokine production by inhibiting phosphorylation of MAPKs and STAT proteins Innate Immun. 2013 Oct 31. [Epub ahead of print] 3 . Chow   LN,   Choi   KY,   Piyadasa   H,   Bossert   M,   Uzonna   J,   Klonisch   T,   Mookherjee   N.   2013.   Human   cathelicidin   LL-37-derived   peptide   IG-19   confers protection in a murine model of collagen-induced arthritis. Mol Immunol. doi: 10.1016/j.molimm.2013. Epub 2013 Oct 1 4 . Okeke,   E.,   Okwor,   I.B.,   Mou,   Z.,   jia,   P.,   and   Uzonna,   J.E.   2013.   CD4 + CD25 +    Regulatory   T   Cells   Attenuates   LPS-induced   Systemic   Inflammatory Responses and Promotes Survival in Murine Escherichia coli  infection. Shock 40(1):65-73 . 5 . Okwor, I., and Uzonna, J.E. 2013. The immunology of Leishmania/HIV co-infection. Immunol Res. May;56(1):163-71 . 6 . Singh,   R.,   Kone,   B.,   Gounni,   A.S.,   and   Uzonna,   J.E.,   2013;   Molecular   regulation   of   Trypanosoma   congolense -induced   nitric   oxide   production   in macrophages. PLoS One. 2013;8(3):e59631 . 7 . Mou,   Z.,   Muleme,   H.M.,   Liu,   D.,   Jia,   P.,   Okwor,   I.B.,   Kuriakose,   S.,   Beverley,   S.M.,   Uzonna,   J.E.   2013.   Parasite-derived   arginase   influences   secondary anti-Leishmania immunity by regulating programmed cell death-1-mediated CD4 +  T cell exhaustion. J Immunol. 2013 Apr 1;190(7):3380-9 . 8 . Umadat,   V.,   Ihedioha,   O.,   Shiu,   R.,   Uzonna,   J.,   and   Myal,   Y.   2013.   The   prolactin-inducible   protein   (PIP):   a   regulatory   molecule   in   adaptive   and   innate immunity. Open J. Immunol. 4:210-217 .
2012 1 . Okwor,   I.,   Jia,   P.,   Onyilagha,   C.,   Kuriakose,   S.,   and   Uzonna,   J.   2012.   Regulatory   T   cells   enhance   susceptibility   to   experimental   Trypanosoma congolense  infection independent of mouse genetic background. PLoS Neg Trop Dis 6(7). 2 . Kuriakose,   S.,   Muleme,   HM.,   Onyilagha,   C.,   Singh,   R.,   Jia,   P.,   and   Uzonna,   J.E.   2012.   Diminazene   aceturate   (Berenil)   modulates   the   host   cellular   and inflammatory responses to Trypanosoma congolense  infection. PLoS One. 7(11) . 3 . Liu,   D.,   and   Uzonna,   J.E.   2012.   The   early   interaction   of   Leishmania   with   macrophages   and   dendritic   cells   and   its   influence   on   the   host   immune response. Front Cell Infect Microbiol 2:83. 4 . Xie,   J.,   Lotoski,   L.C.,   Chooniedass,   R.,   Su,   R.C.,   Simons,   FE.,   Liem,   J.,   Becker,   A.B.,   Uzonna,   J.,   and   HayGlass,   K.T.   2012.   Elevated   antigen-driven   IL-9 responses are prominent in peanut allergic humans. PLoS One 7(10). 5 . Okwor, I., Mou, Z., Liu, D and Uzonna, J.E. 2012. Protective Immunity and Vaccination Against Cutaneous Leishmaniasis. Front Immunol. 3:128.
2010 1 . Mou,   Z.,   Jia,   P.,   Kuriakose,   S.,   Khadem,   F.,   and   Uzonna,   J.E.      2010.   Interleukin-17-mediated   control   of   parasitemia   in   experimental   Trypanosoma congolense  infection in mice. Infect Immun 78(12):5271-9. 2 . Okwor,   I.,   Kuriakose,   S.,   and   Uzonna,   J.   2010.   Repeated   inoculation   of   killed   Leishmania   major   induces   durable   immune   response   that   protects mice against virulent challenge. Vaccine 33:5451-7. 3 . Liu   D.,   and   Uzonna,   J.E.      2010.   The   p110 d    isoform   of   phosphoinositide   3   kinase   controls   the   quality   of   secondary   anit-Leishmania   immunity   by negatively regulating expansion and effector function of memory T cell subsets. J Immunol. 2010 Mar 15;184(6):3098-105 . 4 . Joyee   A.,   Uzonna,   J.E.,   and   Yang,   X.   2010.   Invariant   NKT   cells   preferentially   modulate   the   function   of   CD8 +    dendritic   cell   subset   in   inducing   type   1 immunity against infection. J. Immunol. 184:2095-106. 5 . Zhou,   G.,   Ma,   Y.,   Jia,   P.,   Guan,   Q.,   Peng,   Z,   and   Uzonna,   J.E.   2010.   Enhancement   of   IL-10   bioactivity   using   an   IL-10   peptide-based   vaccine exacerbates Leishmania major  infection and improves airway inflammation in mice. Vaccine 28:1838-1846.
Articles in Journals (After 2010)
Publications Publications R G
2016 1 . Khadem,   F.,   Jia,   P.,   Mou,   Z.,   Barazandeh,   A.   F.,   Liu,   D.,   Keynan,   Y.,   and   Uzonna,   J.E.   Pharmacological inhibition   of   p110δ   subunit   of   PI3K   confers   protection   against   experimental   leishmaniasis.   Journal   of Antimicrobial Chemotherapy. 2016 . 2 . Ihedioha    OC,    Shiu    RP,    Uzonna    JE,    Myal    Y.    2016    Prolactin-Inducible    Protein:    From    Breast    Cancer Biomarker     to     Immune     Modulator-Novel     Insights     from     Knockout     Mice.     DNA     Cell     Biol.     2016 Oct;35(10):537-541 (PMID: 27602994) . 3 . Okwor   I,   and   Uzonna   JE.   2016.   Pathways   leading   to   interleukin-12   production   and   protective   immunity in cutaneous leishmaniasis. Cell Immunol. 2016 Jun 29 (PMID: 27394077). 4 . Kuriakose   SM,   Singh   R,   and   Uzonna   JE.   2016.   Host   Intracellular   Signaling   Events   and   Pro-inflammatory Cytokine Production in African Trypanosomiasis. Front Immunol. 2016 May 19;7:181. 5 . Okwor   I,   and   Uzonna   J.   2016.   Social   and   Economic   Burden   of   Human   Leishmaniasis.   Am   J   Trop   Med Hyg. 2016 Mar;94(3):489-93. 6 . Okeke   EB,   and   Uzonna   JE.   2016.   In   Search   of   a   Cure   for   Sepsis:   Taming   the   Monster   in   Critical   Care Medicine. J Innate Immun. 2016;8(2):156-70 .